Two cases of recurrent deep venous thrombosis in patients under treatment with oral direct thrombin inhibitors

Background: Oral direct thrombin inhibitors are widely used for treatment and prophylaxis of thromboembolic disease.
Methods and Results: Herein, we report two cases of established recurrent deep venous thrombosis despite treatment with oral direct thrombin inhibitors.
Conclusion: Whether this failure was due to this class of newer anticoagulants or their recommended dosages remains to be elucidated.