A microcrystalline cellulose (mcc) as a tablet excipient: review


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Prisca Safriani Wicita., Anis Yohana Chairunisaa and Marline Abdassah

Cellulose is a sustainable, abundant and naturally occurring biopolymer derived from biomass. Microcrystalline cellulose (MCC) is increasingly considered as an important derivative from cellulose in the context of its potential. Through acid hydrolysis, cellulose can be converted to microcrystalline cellulose, which has been used especially in food, cosmetics, and medical industries as a water-retainer, a suspension stabilizer, a flow characteristics controllers in the systems used for final products, and as reinforcing agent for final products such as medical tablets. Attributes like strength, fibrous nature, stiffness, crystallinity, lightness, biodegradability, water insolubility and renew alibility make MCC attractive for applications in diverse industrial fields. Microcrystalline cellulose has enjoyed extensive usage in pharmaceutical industry because of its numerous derivatives which are multifunctional excipients in drug formulations, for example as a binder/diluent, lubricant and disintegration in oral tablet and capsule formulations. The growing nature of pharmaceutical industry and abundant availability of agricultural waste has motivated various researchers to examine those waste as alternative source of cellulose for the production of MCC, besides the cotton and wood materials currently being used. Furthermore, they search function of MCC obtained from the material to evaluate its usefulness as a tablet excipient.

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