Heterosides, containing sulfur and nitrogen heterocycles, have analyptic properties and regulate the function of liver detoxication

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Author: 
Kabachna I V., Bozhkov А.I, Kurguzova N I., Novikova A. V., Kabachnyy V.I and Suprun E.V.

The effect of Heteroside – 321 on the ethanol sleep model as an analeptic and its effect on liver detoxification function in mature rats of Wistar males was investigated. The duration of ethanol sleep, the frequency of respiration during sleep, the activity of alcohol dehydrogenase, alanine aminotransferase and aspartate aminotransferase, the content of aldehyde, serum creatinine and liver lipid peroxide were determined. Sulfocamphocain was used as a classic analeptic. It was shown that the synthesized in our laboratory Heteroside – 321 at a dose of 2 mg / 100 g of body weight had a pronounced analeptic activity, increased the function of liver detoxification and did not have negative side effects on liver function. The ethanol narcosis model can be used in the development and evaluation of new analeptics.

Page: 
481-486
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