Antihyperlipidemic activity of plectranthus scutellarioides (l.) r.br. n-hexanesubfraction on normal and propylthiouracil induced hyperlipidemic rats

×

Error message

  • User warning: The following module is missing from the file system: module_filter. For information about how to fix this, see the documentation page. in _drupal_trigger_error_with_delayed_logging() (line 1138 of /home/ijcmesjournal/public_html/includes/bootstrap.inc).
  • Deprecated function: Function create_function() is deprecated in include_once() (line 1 of /home/ijcmesjournal/public_html/sites/all/themes/bootstrap/templates/system/item-list.func.php).
  • Deprecated function: The each() function is deprecated. This message will be suppressed on further calls in _menu_load_objects() (line 579 of /home/ijcmesjournal/public_html/includes/menu.inc).
  • Deprecated function: Function create_function() is deprecated in include_once() (line 1 of /home/ijcmesjournal/public_html/sites/all/themes/bootstrap/templates/system/status-messages.func.php).
Author: 
Aulia Chintara Wanda., Yoppi Iskandar., Ida Musfiroh and Moelyono Moektiwardoyo

This study examined the activity of n-hexane subfraction Plectranthus scutellarioides on normal and propylthiourasil induced hyperlipidemic rats. Propylthiourasil and high fat diet were used to induced hyperlipidemic, and also given Simvastatin 1 mg/kg body weight of rats. Fraction n-hexane of Plectranthus scutellarioides was separated by using Vacum Liquid Chromatography method (VLC) using percentage gradient eluent of n-hexane : ethyl acetat (100:0 ; 90:10 ; 80:20 ; 70:30 ; 60:40 ; 50:50 ; 40:60 ; 30:70 ; 20:80 ; 10:90 ; 0:100) and 100% ethanol. The result of separation is obtained by five subfraction (SF a, SF b, SF d, SF e, and SF f) and 3 (SF b, SF c, and SF d) of 5 subtractions were done testing with oral administration for 2 weeks. The result show that SF b provides the best results in lowering cholesterol total levels, trygliserid, LDL-C, and VLDL-C. SF c provide the best result to incrase HDL-C level.

Page: 
383-386
Download PDF: