Garcinia mangostana Linn. (GML) is a tropical tree from Southeast Asia has a distinctive taste and is known as "the queen of fruits". The spread of mangosteen plants in India, Myanmar, Malaysia, Philippines, Sri Lanka, and Thailand. The main phytochemicals present in this species are xanthone isoprenylation, a secondary metabolite class with many reports of biological effects. In Ayurvedic medicine, mangosteen is used as antidiarrhea, anti-inflammatory, cholera and dysentery medications. Traditional Thai medicine has also used a mangosteen pericarp to treat skin infections, wounds, and diarrhea for many years. Based on several studies have shown that the xanthon contained in the mangosteen fruit has extraordinary biological activity. Among others are antimicrobial, antimalarial, anti-inflammatory, antitumor, anticancer, antioxidant and antidiabetic.