Evaluation of two different dosages of dexmedetomidine in attenuation of pressor response during endotracheal intubation and reducing inj. thiopentone dosages during induction of anaesthesia

Sudharsan Raj M.R, Gowthaman R and Sekaran N.K

Tracheal intubation and direct laryngoscopy are considered as the most critical event during administration of general anaesthesia. Dexmedetomidine is an alfa-2 adrenergic agonist use for control of haemodynamic response to laryngoscopy and tracheal intubation. Our study consisted 60 patients of ASA grade I or II, scheduled for surgery, divided into two groups of 30 patients each. Group A received injection dexmedetomidine 0.5 µg.kg-1 over 10 minutes and Group B received injection dexmedetomidine 0.1 µg.kg-1 over 10 min. Induction was done with Inj. thiopentone 5mg/kg/wt and Inj. succinylcholine 2 mg/k/wt. Paremeters like arterial blood pressure and requirement of Inj. thiopentone dosage and post- operative sedation score were studied. Data obtained was analaysed using unpaired t-test we have observed statistically highly significant (P<0.01). There is increase in mean arterial blood pressure in group A compared to group B. There was a reduction to Inj. thiopentone dosage requirements in group B compared to group A. Post operative sedation score was studied with ramsay sedation score. There was no significant changes in SpO2 in both groups at all intervals (p>0.05). We conclude that dexmedetomidine 1µg.kg-1 is more effective than 0.5 µg.kg-1 in attenuating haemodynamic responses to laryngoscopy and tracheal intubation, and reducing inj. thiopentone dosages during induction of anaesthesia without any systemic side effects and better post operative sedation score.

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