The present study investigated the antihyperlipidemic activity of Plectranthus scutellarioides on normal and propylthiouracil induced hiperlipidemic rats. Plectranthus scutellarioides leaves were extracted with ethanol 70% by macerator apparatus. Propylthiouracil and a high-fat diet were used to induced hyperlipidemic rats and followed by oral administration of simvastatin 1 mg/kg, PSE 400 mg/kg, PSE 500 mg/kg and PSE 600 mg/kg for two weeks. Total cholesterol, triglycerides, and HDL cholesterol were measured and also calculated by formula LDL cholesterol, VLDL cholesterol, atherogenic index and coronary risk index. The result showed that PSE 600 mg/kg had better activity to decrease total cholesterol. PSE 500 mg/kg showed better activity to decrease triglycerides, VLDL cholesterol and LDL cholesterol. PSE 400 mg/kg showed better activity to increase HDL cholesterol. Therefore, Plectranthus scutellarioides extract dose 400 mg/kg, 500 mg/kg and 600 mg/kg have antihyperlipidemic activity with decreasing total cholesterol, triglycerides, LDL cholesterol, VLDL cholesterol and increasing HDL cholesterol.